CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00794
Pert ID:	BRD-K34581968
Compound Name:	BMS-536924
Targets:	AKT1\|CCNE1\|CDK2\|CYP3A4\|ERBB2\|IGF1R\|KDR\|LCK\|MAPK1\|MET\|PDGFRA\|PDGFRB
MoA:	IGF-1 inhibitor
SMILES:	Cc1cc(cc2[nH]c(nc12)-c1c(NC[C@@H](O)c2cccc(Cl)c2)cc[nH]c1=O)N1CCOCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
9065	BRD-K34581968	A375	12 uM	6 h	0.22	0.94	0.06	0.0	0.0	0.0
9719	BRD-K34581968	H1299	12 uM	6 h	0.0	0.0	0.0	0.34	1.22	1.15
9994	BRD-K34581968	HA1E	12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
10507	BRD-K34581968	HCT116	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11122	BRD-K34581968	HT29	12 uM	6 h	-0.17	-0.69	0.0	0.31	1.11	0.72
11278	BRD-K34581968	MCF??7.00	12 uM	6 h	0.0	0.0	0.0	-0.31	-1.05	0.7
11474	BRD-K34581968	NCIH2073	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
11754	BRD-K34581968	NCIH508	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12038	BRD-K34581968	NCIH596	12 uM	6 h	0.0	0.0	0.0	0.32	1.12	0.74
12304	BRD-K34581968	NOMO1	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
12781	BRD-K34581968	SW480	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13118	BRD-K34581968	THP1	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
13262	BRD-K34581968	U937	12 uM	6 h	0.0	0.0	0.0	0.24	0.87	0.17
13614	BRD-K34581968	VCAP	12 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
118103	BRD-K34581968	A549	1.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118191	BRD-K34581968	HCC515	0.37 uM	24 h	0.22	0.91	0.04	0.0	0.0	0.0
118241	BRD-K34581968	HEPG2	12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
118366	BRD-K34581968	PC3	1.25 uM	24 h	0.0	0.0	0.0	-0.23	-0.79	0.11

Summary