CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00804
Pert ID:	BRD-K40738845
Compound Name:	BMS-777607
Targets:	AXL\|MERTK\|MET\|MST1R\|TYRO3
MoA:	AXL kinase inhibitor; c-Met inhibitor; FLT3 inhibitor; hepatocyte growth factor receptor inhibitor; macrophage migration inhibiting factor inhibitor; tyrosine kinase inhibitor
SMILES:	CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
90864	BRD-K40738845	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91803	BRD-K40738845	HS578T	2.22 uM	6 h	0.0	0.0	0.0	-0.29	-0.96	0.44
91935	BRD-K40738845	SKBR3	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92958	BRD-K40738845	ASC	10 uM	24 h	0.2	0.83	0.0	0.0	0.0	0.0
93004	BRD-K40738845	CD34	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93177	BRD-K40738845	HEPG2	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93230	BRD-K40738845	HUVEC	3.33 uM	24 h	-0.22	-0.91	0.06	0.21	0.76	0.05
93364	BRD-K40738845	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93422	BRD-K40738845	NPC	10 uM	24 h	0.26	1.07	0.19	-0.23	-0.79	0.1
93451	BRD-K40738845	PC3	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.98	0.49
93490	BRD-K40738845	SKL	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123289	BRD-K40738845	HEK293	0.04 uM	24 h	0.0	0.0	0.0	-0.38	-1.28	1.45
123458	BRD-K40738845	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131526	BRD-K40738845	A375	2.22 uM	24 h	0.0	0.0	0.0	-0.38	-1.27	1.39
131551	BRD-K40738845	A549	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131585	BRD-K40738845	HA1E	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131659	BRD-K40738845	HELA	0.74 uM	24 h	0.25	1.03	0.14	0.0	0.0	0.0
131686	BRD-K40738845	HT29	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131777	BRD-K40738845	JURKAT	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131856	BRD-K40738845	MCF??7.00	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131953	BRD-K40738845	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary