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CMap Candidate Details

Structure:
CMap ID: C00835
Pert ID: BRD-K96123349
Compound Name: brequinar
Targets: DHODH
MoA: dihydroorotate dehydrogenase inhibitor
SMILES: Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
88075 BRD-K96123349 MCF??7.00 4 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
128391 BRD-K96123349 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128448 BRD-K96123349 HEK293 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
128509 BRD-K96123349 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128558 BRD-K96123349 JURKAT 10 uM 24 h -0.16 -0.66 0.0 0.33 1.16 0.9
128598 BRD-K96123349 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128650 BRD-K96123349 MDAMB231 3.33 uM 24 h 0.17 0.72 0.0 0.32 1.14 0.86
128685 BRD-K96123349 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128730 BRD-K96123349 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128775 BRD-K96123349 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136187 BRD-K96123349 A375 0.08 uM 24 h 0.22 0.92 0.04 0.27 0.96 0.34
136233 BRD-K96123349 HA1E 0.74 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
136268 BRD-K96123349 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.22 0.78 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).