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CMap Candidate Details

Structure:
CMap ID: C00836
Pert ID: BRD-K96936751
Compound Name: bretazenil
Targets: GABRA1|GABRA2|GABRA3|GABRA4|GABRA5|GABRA6
MoA: GABA benzodiazepine site receptor partial agonist
SMILES: CC(C)(C)OC(=O)c1ncn-2c1[C@@H]1CCCN1C(=O)c1c(Br)cccc-21
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
128399 BRD-K96936751 A549 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.56
128459 BRD-K96936751 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128569 BRD-K96936751 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
128661 BRD-K96936751 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128693 BRD-K96936751 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128741 BRD-K96936751 THP1 0.04 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
128779 BRD-K96936751 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.42 -1.4 2.02
136198 BRD-K96936751 A375 0.08 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
136243 BRD-K96936751 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136276 BRD-K96936751 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.15
136299 BRD-K96936751 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
136321 BRD-K96936751 MCF10A 0.03 uM 24 h -0.33 -1.38 1.08 0.0 0.0 0.0
136354 BRD-K96936751 MCF??7.00 0.74 uM 24 h 0.28 1.19 0.41 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).