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CMap Candidate Details

Structure:
CMap ID: C00844
Pert ID: BRD-K28428262
Compound Name: brivanib
Targets: CYP3A4|FGFR1|FLT1|KCNH2|KDR
MoA: FGFR inhibitor; VEGFR inhibitor
SMILES: C[C@@H](O)COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
34074 BRD-K28428262 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34340 BRD-K28428262 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35554 BRD-K28428262 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35759 BRD-K28428262 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36236 BRD-K28428262 PHH 10 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
36530 BRD-K28428262 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36799 BRD-K28428262 VCAP 10 uM 24 h 0.0 0.0 0.0 0.39 1.38 2.16
96127 BRD-K28428262 A549 10 uM 24 h 0.21 0.86 0.01 0.27 0.95 0.31
117684 BRD-K28428262 A375 10 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
117828 BRD-K28428262 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117878 BRD-K28428262 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117975 BRD-K28428262 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.23 0.83 0.11
121978 BRD-K28428262 HELA 10 uM 24 h -0.24 -1.0 0.15 0.25 0.89 0.19
122001 BRD-K28428262 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122035 BRD-K28428262 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.31 1.08 0.67
122134 BRD-K28428262 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122158 BRD-K28428262 PC3 3.33 uM 24 h -0.23 -0.95 0.09 0.26 0.94 0.28
122183 BRD-K28428262 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122211 BRD-K28428262 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
130249 BRD-K28428262 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130337 BRD-K28428262 JURKAT 0.25 uM 24 h 0.2 0.84 0.0 0.35 1.25 1.29
130388 BRD-K28428262 MCF10A 2.22 uM 24 h 0.23 0.94 0.06 0.27 0.97 0.35
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).