CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00872
Pert ID:	BRD-A36057565
Compound Name:	bruceantin
Targets:
MoA:	protein synthesis inhibitor
SMILES:	COC(=O)[C@]12OC[C@@]34[C@H]1[C@@H](OC(=O)\C=C(/C)C(C)C)C(=O)O[C@@H]3C[C@H]1C(C)C(=O)C(=O)C[C@]1(C)[C@H]4[C@@H](O)[C@@H]2O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125042	BRD-A36057565	HELA	0.04 uM	24 h	0.26	1.07	0.2	0.0	0.0	0.0
125086	BRD-A36057565	MCF10A	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125186	BRD-A36057565	THP1	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
132988	BRD-A36057565	A375	0.01 uM	24 h	0.28	1.17	0.37	-0.39	-1.31	1.71
133003	BRD-A36057565	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133024	BRD-A36057565	HA1E	0.08 uM	24 h	0.28	1.15	0.33	0.0	0.0	0.0
133076	BRD-A36057565	HEK293	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133132	BRD-A36057565	HT29	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133182	BRD-A36057565	JURKAT	0.01 uM	24 h	0.3	1.27	0.58	0.0	0.0	0.0
133244	BRD-A36057565	MCF??7.00	0.01 uM	24 h	0.33	1.39	1.02	0.0	0.0	0.0
133273	BRD-A36057565	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133303	BRD-A36057565	PC3	0.08 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.93
133327	BRD-A36057565	YAPC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary