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CMap Candidate Details

Structure:
CMap ID: C00873
Pert ID: BRD-A41995253
Compound Name: brucine
Targets: CHRM1|CHRM2|CHRM3|CHRM4|CHRM5
MoA: glycine receptor antagonist
SMILES: COc1cc2N3C4[C@@H]5C(CC3=O)OCC=C3CN6CC[C@]4([C@@H]6C[C@H]53)c2cc1OC
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5155 BRD-A41995253 A375 10 uM 6 h -0.27 -1.13 0.41 0.0 0.0 0.0
5400 BRD-A41995253 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5726 BRD-A41995253 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5981 BRD-A41995253 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6242 BRD-A41995253 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6328 BRD-A41995253 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39395 BRD-A41995253 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39892 BRD-A41995253 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.72 0.04
40567 BRD-A41995253 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
40694 BRD-A41995253 NEU 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
40992 BRD-A41995253 NPC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.71
41316 BRD-A41995253 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).