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CMap Candidate Details

Structure:
CMap ID: C00893
Pert ID: BRD-K38197229
Compound Name: bumetanide
Targets: CFTR|GPR35|SLC12A1|SLC12A2|SLC12A4|SLC12A5
MoA: solute carrier family member inhibitor
SMILES: CCCCNc1cc(cc(c1Oc1ccccc1)S(N)(=O)=O)C(O)=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4429 BRD-K38197229 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5080 BRD-K38197229 VCAP 10 uM 6 h -0.18 -0.73 0.0 0.28 1.0 0.42
37380 BRD-K38197229 A549 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.2 1.18
37647 BRD-K38197229 ASC 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
37899 BRD-K38197229 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38472 BRD-K38197229 NPC 10 uM 24 h 0.21 0.89 0.02 0.26 0.93 0.28
38714 BRD-K38197229 PHH 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.27
38947 BRD-K38197229 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91187 BRD-K38197229 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
99909 BRD-K38197229 U2OS 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123592 BRD-K38197229 HEK293 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123628 BRD-K38197229 HELA 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
123661 BRD-K38197229 HT29 3.33 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
123707 BRD-K38197229 MCF10A 1.11 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
123748 BRD-K38197229 PC3 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.16
131994 BRD-K38197229 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132022 BRD-K38197229 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132092 BRD-K38197229 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132149 BRD-K38197229 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).