CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00895
Pert ID:	BRD-K42191735
Compound Name:	buparlisib
Targets:	PIK3CA\|PIK3CG
MoA:	PI3K inhibitor
SMILES:	Nc1cc(c(cn1)-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91805	BRD-K42191735	HS578T	10 uM	6 h	0.0	0.0	0.0	-0.25	-0.86	0.2
91991	BRD-K42191735	A375	1.11 uM	24 h	0.0	0.0	0.0	-0.5	-1.67	15.65
92019	BRD-K42191735	BT20	3.33 uM	24 h	0.26	1.08	0.21	-0.29	-0.99	0.5
92067	BRD-K42191735	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92099	BRD-K42191735	HCC515	10 uM	24 h	0.0	0.0	0.0	-0.22	-0.74	0.06
92215	BRD-K42191735	MCF10A	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
92310	BRD-K42191735	MDAMB231	10 uM	3 h	0.0	0.0	0.0	0.0	0.0	0.0
92366	BRD-K42191735	SKBR3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117060	BRD-K42191735	A549	1.11 uM	24 h	0.0	0.0	0.0	-0.43	-1.43	15.35
117187	BRD-K42191735	HEPG2	3.33 uM	24 h	-0.22	-0.9	0.04	-0.36	-1.2	1.17
117305	BRD-K42191735	PC3	10 uM	24 h	0.0	0.0	0.0	-0.32	-1.08	0.8
121700	BRD-K42191735	YAPC	10 uM	24 h	0.0	0.0	0.0	-0.46	-1.56	15.65
129600	BRD-K42191735	HELA	2.22 uM	24 h	0.0	0.0	0.0	-0.43	-1.45	15.35
129630	BRD-K42191735	HT29	2.22 uM	24 h	-0.27	-1.14	0.42	0.0	0.0	0.0
129659	BRD-K42191735	MCF??7.00	2.22 uM	24 h	0.0	0.0	0.0	-0.39	-1.33	1.71

Summary