CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00916
Pert ID:	BRD-K42417338
Compound Name:	butorphanol-(+)-tartrate
Targets:	OPRD1\|OPRK1\|OPRM1
MoA:	opioid receptor agonist; opioid receptor antagonist
SMILES:	Oc1ccc2C[C@H]3N(CC4CCC4)CC[C@@]4(CCCC[C@@]34O)c2c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95469	BRD-K42417338	U2OS	10 uM	6 h	-0.21	-0.89	0.03	0.0	0.0	0.0
123243	BRD-K42417338	A375	0.37 uM	24 h	0.0	0.0	0.0	0.22	0.77	0.05
123318	BRD-K42417338	HELA	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123430	BRD-K42417338	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.31	1.08	0.65
123467	BRD-K42417338	THP1	10 uM	24 h	0.24	1.0	0.11	-0.29	-0.98	0.47
123500	BRD-K42417338	YAPC	0.04 uM	24 h	0.0	0.0	0.0	-0.44	-1.48	15.35
131557	BRD-K42417338	A549	2.22 uM	24 h	-0.26	-1.1	0.33	0.0	0.0	0.0
131596	BRD-K42417338	HA1E	0.25 uM	24 h	0.28	1.16	0.36	0.0	0.0	0.0
131638	BRD-K42417338	HEK293	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131689	BRD-K42417338	HT29	0.03 uM	24 h	-0.22	-0.9	0.05	0.0	0.0	0.0
131737	BRD-K42417338	HUVEC	0.74 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
131791	BRD-K42417338	JURKAT	0.01 uM	24 h	0.0	0.0	0.0	-0.25	-0.85	0.19
131830	BRD-K42417338	MCF10A	0.03 uM	24 h	0.2	0.85	0.01	0.25	0.88	0.19
131866	BRD-K42417338	MCF??7.00	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131899	BRD-K42417338	MDAMB231	0.25 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary