CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00984
Pert ID:	BRD-K75037734
Compound Name:	carbachol
Targets:	CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|CHRNA2
MoA:	cholinergic receptor agonist
SMILES:	C[N+](C)(C)CCOC(N)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
91048	BRD-K75037734	HUH7	25 uM	72 h	0.0	0.0	0.0	0.25	0.89	0.2
127014	BRD-K75037734	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127133	BRD-K75037734	HT29	0.04 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
127180	BRD-K75037734	MCF10A	10 uM	24 h	0.0	0.0	0.0	0.36	1.28	1.42
127233	BRD-K75037734	PC3	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
127275	BRD-K75037734	THP1	1.11 uM	24 h	0.17	0.71	0.0	0.27	0.95	0.31
135037	BRD-K75037734	A549	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135079	BRD-K75037734	HA1E	0.08 uM	24 h	0.0	0.0	0.0	0.25	0.87	0.17
135103	BRD-K75037734	HEK293	0.25 uM	24 h	0.0	0.0	0.0	-0.32	-1.07	0.76
135128	BRD-K75037734	HELA	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135167	BRD-K75037734	JURKAT	0.25 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.57
135227	BRD-K75037734	MCF??7.00	0.74 uM	24 h	0.23	0.94	0.06	0.31	1.1	0.69
135256	BRD-K75037734	MDAMB231	0.03 uM	24 h	0.36	1.51	1.43	0.2	0.72	0.02
135324	BRD-K75037734	YAPC	0.25 uM	24 h	-0.2	-0.82	0.0	-0.27	-0.91	0.31

Summary