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CMap Candidate Details

Structure:
CMap ID: C00986
Pert ID: BRD-K71799949
Compound Name: carbamazepine
Targets: SCN10A|SCN11A|SCN1A|SCN2A|SCN3A|SCN4A|SCN5A|SCN7A|SCN8A|SCN9A
MoA: carboxamide antiepileptic
SMILES: NC(=O)N1c2ccccc2C=Cc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
10581 BRD-K71799949 HCT116 100 uM 6 h 0.0 0.0 0.0 0.35 1.25 1.29
10839 BRD-K71799949 HEPG2 100 uM 6 h 0.23 0.97 0.08 -0.22 -0.74 0.05
11561 BRD-K71799949 NCIH2073 100 uM 6 h 0.0 0.0 0.0 0.36 1.28 1.37
12117 BRD-K71799949 NCIH596 100 uM 6 h 0.0 0.0 0.0 0.35 1.24 1.27
13345 BRD-K71799949 U937 100 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37729 BRD-K71799949 ASC 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.45
50401 BRD-K71799949 HCC515 10 uM 6 h 0.28 1.16 0.35 0.0 0.0 0.0
51172 BRD-K71799949 VCAP 10 uM 6 h 0.23 0.98 0.09 0.0 0.0 0.0
51331 BRD-K71799949 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.32 -1.08 0.79
90804 BRD-K71799949 HPTEC 320 uM 6 h 0.0 0.0 0.0 -0.43 -1.46 15.35
91427 BRD-K71799949 HUH7 15 uM 72 h 0.0 0.0 0.0 -0.37 -1.25 1.35
98824 BRD-K71799949 NPC 10 uM 6 h 0.0 0.0 0.0 0.31 1.08 0.66
98930 BRD-K71799949 NEU 10 uM 24 h -0.2 -0.84 0.0 0.3 1.08 0.65
99424 BRD-K71799949 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126813 BRD-K71799949 MCF10A 1.11 uM 24 h -0.26 -1.07 0.28 0.0 0.0 0.0
126968 BRD-K71799949 THP1 10 uM 24 h 0.25 1.03 0.13 0.21 0.74 0.03
134685 BRD-K71799949 A375 2.22 uM 24 h -0.27 -1.13 0.41 -0.31 -1.04 0.68
134709 BRD-K71799949 A549 0.08 uM 24 h -0.19 -0.79 0.0 0.0 0.0 0.0
134742 BRD-K71799949 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134776 BRD-K71799949 HEK293 0.03 uM 24 h 0.0 0.0 0.0 -0.4 -1.35 2.02
134805 BRD-K71799949 HELA 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134834 BRD-K71799949 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134882 BRD-K71799949 HUVEC 0.03 uM 24 h -0.25 -1.06 0.26 0.0 0.0 0.0
134908 BRD-K71799949 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134945 BRD-K71799949 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134971 BRD-K71799949 PC3 2.22 uM 24 h 0.22 0.9 0.03 -0.36 -1.2 1.22
135000 BRD-K71799949 YAPC 2.22 uM 24 h 0.33 1.39 1.02 -0.26 -0.87 0.23
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).