CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00100
Pert ID:	BRD-K82928847
Compound Name:	ACY-1215
Targets:	HDAC1\|HDAC2\|HDAC3\|HDAC6\|HDAC8
MoA:	HDAC inhibitor
SMILES:	ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
93647	BRD-K82928847	ASC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
93705	BRD-K82928847	CD34	10 uM	24 h	0.24	1.0	0.11	-0.25	-0.84	0.18
93787	BRD-K82928847	HCC515	1.11 uM	24 h	0.0	0.0	0.0	0.21	0.76	0.05
93920	BRD-K82928847	HEPG2	1.11 uM	24 h	-0.26	-1.06	0.26	0.0	0.0	0.0
94097	BRD-K82928847	NEU	0.37 uM	24 h	0.27	1.14	0.32	0.0	0.0	0.0
94135	BRD-K82928847	NPC	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94230	BRD-K82928847	SHSY5Y	3.33 uM	24 h	-0.29	-1.22	0.61	0.0	0.0	0.0
94281	BRD-K82928847	SKL	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61
94376	BRD-K82928847	YAPC	10 uM	24 h	0.22	0.91	0.04	0.0	0.0	0.0
97255	BRD-K82928847	HAP1	0.66 uM	24 h	0.0	0.0	0.0	0.31	1.09	0.67
125579	BRD-K82928847	A375	10 uM	24 h	0.22	0.92	0.04	0.0	0.0	0.0
125612	BRD-K82928847	A549	3.33 uM	24 h	0.0	0.0	0.0	-0.3	-1.01	0.57
125649	BRD-K82928847	HEK293	10 uM	24 h	0.0	0.0	0.0	-0.4	-1.34	1.85
125730	BRD-K82928847	HUVEC	3.33 uM	24 h	0.23	0.94	0.06	-0.27	-0.89	0.27
125776	BRD-K82928847	JURKAT	3.33 uM	24 h	0.21	0.87	0.01	0.0	0.0	0.0
125826	BRD-K82928847	MCF??7.00	3.33 uM	24 h	-0.25	-1.02	0.19	0.0	0.0	0.0
125872	BRD-K82928847	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133696	BRD-K82928847	HA1E	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133762	BRD-K82928847	HELA	0.74 uM	24 h	0.21	0.88	0.02	0.0	0.0	0.0
133795	BRD-K82928847	HT29	2.22 uM	24 h	-0.24	-1.01	0.16	-0.24	-0.79	0.11
133854	BRD-K82928847	MCF10A	2.22 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.5
133912	BRD-K82928847	MDAMB231	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133976	BRD-K82928847	THP1	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary