CMap Candidate Details
Structure:
| CMap ID: | C01005 |
| Pert ID: | BRD-K15179879 |
| Compound Name: | carfilzomib |
| Targets: | PSMA1|PSMA2|PSMA3|PSMA4|PSMA5|PSMA6|PSMA7|PSMA8|PSMB1|PSMB10|PSMB11|PSMB2|PSMB3|PSMB4|PSMB5|PSMB6|PSMB7|PSMB8|PSMB9 |
| MoA: | proteasome inhibitor |
| SMILES: | CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |
| InchiKey: | |
| Compound Aliases: |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122274 | BRD-K15179879 | A375 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122290 | BRD-K15179879 | A549 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122308 | BRD-K15179879 | HA1E | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122404 | BRD-K15179879 | MCF??7.00 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122428 | BRD-K15179879 | MDAMB231 | 0.37 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122499 | BRD-K15179879 | THP1 | 0.04 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130643 | BRD-K15179879 | HEK293 | 0.74 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130685 | BRD-K15179879 | HELA | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130728 | BRD-K15179879 | HT29 | 0.03 uM | 24 h | 0.2 | 0.84 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130751 | BRD-K15179879 | MCF10A | 0.08 uM | 24 h | -0.28 | -1.16 | 0.45 | 0.0 | 0.0 | 0.0 |
| 130822 | BRD-K15179879 | PC3 | 0.08 uM | 24 h | 0.18 | 0.73 | 0.0 | 0.0 | 0.0 | 0.0 |
| 130849 | BRD-K15179879 | YAPC | 0.03 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |