CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00104
Pert ID:	BRD-K33127281
Compound Name:	adapalene
Targets:	RARA\|RARB\|RARG\|RXRA\|RXRB\|RXRG
MoA:	retinoid receptor agonist
SMILES:	COc1ccc(cc1C12CC3CC(CC(C3)C1)C2)-c1ccc2cc(ccc2c1)C(O)=O
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
98889	BRD-K33127281	NEU	10 uM	24 h	0.0	0.0	0.0	-0.28	-0.94	0.37
99141	BRD-K33127281	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121928	BRD-K33127281	A549	10 uM	24 h	0.18	0.75	0.0	0.28	0.99	0.4
121942	BRD-K33127281	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121970	BRD-K33127281	HEK293	10 uM	24 h	0.2	0.83	0.0	-0.26	-0.86	0.22
121993	BRD-K33127281	HELA	3.33 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.25
122023	BRD-K33127281	HT29	3.33 uM	24 h	-0.17	-0.73	0.0	0.29	1.02	0.47
122075	BRD-K33127281	HUVEC	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122094	BRD-K33127281	MCF10A	10 uM	24 h	-0.18	-0.76	0.0	0.0	0.0	0.0
122124	BRD-K33127281	MCF??7.00	0.37 uM	24 h	0.0	0.0	0.0	-0.4	-1.34	1.85
122151	BRD-K33127281	MDAMB231	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122176	BRD-K33127281	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130190	BRD-K33127281	A375	2.22 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.71
130376	BRD-K33127281	JURKAT	0.01 uM	24 h	-0.33	-1.38	1.08	0.21	0.73	0.03
130507	BRD-K33127281	THP1	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130540	BRD-K33127281	YAPC	2.22 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.61

Summary