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CMap Candidate Details

Structure:
CMap ID: C01042
Pert ID: BRD-K45746021
Compound Name: CC-401
Targets: MAPK8
MoA: JNK inhibitor
SMILES: C(CN1CCCCC1)Oc1cccc(c1)-c1n[nH]c2ccc(cc12)-c1ncn[nH]1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
94454 BRD-K45746021 A549 10 uM 24 h -0.23 -0.94 0.08 -0.25 -0.83 0.17
94491 BRD-K45746021 ASC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
94560 BRD-K45746021 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94606 BRD-K45746021 HCC515 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.06
94755 BRD-K45746021 HME1 10 uM 24 h 0.0 0.0 0.0 0.35 1.22 1.15
94847 BRD-K45746021 HUVEC 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.05 0.7
94944 BRD-K45746021 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95025 BRD-K45746021 NEU 0.12 uM 24 h -0.22 -0.9 0.04 -0.22 -0.74 0.06
95082 BRD-K45746021 NPC 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.06 0.74
95173 BRD-K45746021 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95240 BRD-K45746021 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95282 BRD-K45746021 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.21
95826 BRD-K45746021 A375 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
125274 BRD-K45746021 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
125300 BRD-K45746021 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
125351 BRD-K45746021 HELA 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.08
125371 BRD-K45746021 HT29 10 uM 24 h -0.25 -1.06 0.25 0.4 1.43 2.2
125393 BRD-K45746021 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125435 BRD-K45746021 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125489 BRD-K45746021 PC3 10 uM 24 h 0.25 1.06 0.19 0.0 0.0 0.0
125544 BRD-K45746021 YAPC 10 uM 24 h 0.0 0.0 0.0 0.39 1.4 2.17
133543 BRD-K45746021 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).