CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01063
Pert ID:	BRD-K86930074
Compound Name:	cediranib
Targets:	CSF1R\|FLT1\|FLT3\|FLT4\|KDR\|KIT\|PDGFRA\|PDGFRB
MoA:	KIT inhibitor; VEGFR inhibitor
SMILES:	COc1cc2c(Oc3ccc4[nH]c(C)cc4c3F)ncnc2cc1OCCCN1CCCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
34201	BRD-K86930074	ASC	10 uM	24 h	0.27	1.14	0.32	0.0	0.0	0.0
34706	BRD-K86930074	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34983	BRD-K86930074	HEPG2	10 uM	6 h	0.17	0.73	0.0	0.0	0.0	0.0
35632	BRD-K86930074	NEU	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
35856	BRD-K86930074	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36373	BRD-K86930074	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36673	BRD-K86930074	SKB	10 uM	24 h	0.0	0.0	0.0	0.33	1.16	0.9
36888	BRD-K86930074	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95717	BRD-K86930074	U2OS	1.11 uM	6 h	0.22	0.91	0.03	0.4	1.43	2.21
125574	BRD-K86930074	A375	10 uM	24 h	0.0	0.0	0.0	-0.33	-1.12	0.96
125611	BRD-K86930074	A549	10 uM	24 h	0.22	0.9	0.02	0.0	0.0	0.0
125645	BRD-K86930074	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125693	BRD-K86930074	HT29	10 uM	24 h	0.0	0.0	0.0	0.32	1.14	0.87
125723	BRD-K86930074	HUVEC	3.33 uM	24 h	0.0	0.0	0.0	-0.35	-1.16	1.11
125770	BRD-K86930074	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125823	BRD-K86930074	MCF??7.00	3.33 uM	24 h	0.0	0.0	0.0	-0.24	-0.82	0.14
125847	BRD-K86930074	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.29	1.04	0.56
125869	BRD-K86930074	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125922	BRD-K86930074	YAPC	10 uM	24 h	-0.25	-1.04	0.22	0.41	1.47	2.24
133693	BRD-K86930074	HA1E	0.25 uM	24 h	0.0	0.0	0.0	-0.31	-1.05	0.68
133758	BRD-K86930074	HELA	2.22 uM	24 h	0.0	0.0	0.0	0.34	1.21	1.15
133850	BRD-K86930074	MCF10A	0.03 uM	24 h	-0.21	-0.88	0.03	0.41	1.44	2.21
133971	BRD-K86930074	THP1	2.22 uM	24 h	-0.23	-0.96	0.09	-0.32	-1.06	0.75

Summary