CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01114
Pert ID:	BRD-K72827473
Compound Name:	CEP-37440
Targets:	ALK
MoA:	ALK tyrosine kinase receptor inhibitor
SMILES:	CNC(=O)c1ccccc1Nc1nc(Nc2ccc3C[C@H](CCCc3c2OC)N2CCN(CCO)CC2)ncc1Cl
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
95607	BRD-K72827473	MCF??7.00	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
95637	BRD-K72827473	U2OS	10 uM	24 h	0.0	0.0	0.0	-0.44	-1.49	15.35
126659	BRD-K72827473	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
126752	BRD-K72827473	HT29	3.33 uM	24 h	0.0	0.0	0.0	0.21	0.73	0.03
126789	BRD-K72827473	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.24	0.85	0.14
126816	BRD-K72827473	MCF10A	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
126921	BRD-K72827473	PC3	10 uM	24 h	0.18	0.75	0.0	0.0	0.0	0.0
126972	BRD-K72827473	THP1	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.13
134686	BRD-K72827473	A375	2.22 uM	24 h	-0.28	-1.15	0.43	-0.31	-1.04	0.66
134745	BRD-K72827473	HA1E	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134780	BRD-K72827473	HEK293	0.01 uM	24 h	0.0	0.0	0.0	-0.27	-0.92	0.33
134808	BRD-K72827473	HELA	2.22 uM	24 h	0.0	0.0	0.0	-0.33	-1.11	0.92
134886	BRD-K72827473	HUVEC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
134946	BRD-K72827473	MDAMB231	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
135003	BRD-K72827473	YAPC	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary