CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01134
Pert ID:	BRD-K64341947
Compound Name:	CFM-1571
Targets:
MoA:	guanylate cyclase activator
SMILES:	COc1ccc(NC(=O)c2cc(OCCCN(C)C)nn2Cc2ccccc2)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1602	BRD-K64341947	HA1E	10 uM	24 h	0.0	0.0	0.0	0.52	1.84	2.88
1940	BRD-K64341947	HCC515	10 uM	24 h	0.3	1.26	0.58	0.31	1.09	0.67
2178	BRD-K64341947	PC3	10 uM	24 h	0.0	0.0	0.0	0.27	0.94	0.29
2665	BRD-K64341947	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
41820	BRD-K64341947	A375	10 uM	6 h	0.0	0.0	0.0	-0.23	-0.76	0.07
42125	BRD-K64341947	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42432	BRD-K64341947	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42748	BRD-K64341947	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.28	-0.94	0.37
43047	BRD-K64341947	HT29	10 uM	6 h	0.0	0.0	0.0	0.3	1.05	0.58
43345	BRD-K64341947	MCF??7.00	10 uM	6 h	-0.25	-1.04	0.21	0.0	0.0	0.0
43612	BRD-K64341947	NPC	10 uM	24 h	-0.25	-1.06	0.25	0.0	0.0	0.0
43914	BRD-K64341947	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
44170	BRD-K64341947	SKB	10 uM	24 h	0.23	0.94	0.06	0.34	1.21	1.15
99332	BRD-K64341947	U2OS	10 uM	6 h	0.0	0.0	0.0	0.29	1.01	0.46

Summary