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CMap Candidate Details

Structure:
CMap ID: C01140
Pert ID: BRD-A50737080
Compound Name: CGK-733
Targets: ATM|ATR
MoA: ATM kinase inhibitor; ATR kinase inhibitor
SMILES: [O-][N+](=O)c1cc(NC(=S)NC(NC(=O)C(c2ccccc2)c2ccccc2)C(Cl)(Cl)Cl)ccc1F
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5000 BRD-A50737080 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37084 BRD-A50737080 A375 10 uM 6 h -0.24 -1.02 0.17 0.0 0.0 0.0
38022 BRD-A50737080 HT29 10 uM 6 h 0.0 0.0 0.0 -0.45 -1.5 15.35
38869 BRD-A50737080 SKB 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
53550 BRD-A50737080 HUH7 10 uM 6 h -0.25 -1.03 0.2 -0.61 -2.04 15.65
53710 BRD-A50737080 PHH 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
93630 BRD-A50737080 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93673 BRD-A50737080 ASC 1.11 uM 24 h 0.0 0.0 0.0 0.3 1.08 0.65
93738 BRD-A50737080 CD34 10 uM 24 h 0.0 0.0 0.0 0.29 1.01 0.45
93772 BRD-A50737080 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93812 BRD-A50737080 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93863 BRD-A50737080 HEK293 1.11 uM 24 h -0.23 -0.95 0.09 0.0 0.0 0.0
93903 BRD-A50737080 HELA 0.37 uM 24 h -0.26 -1.07 0.27 0.0 0.0 0.0
93945 BRD-A50737080 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93972 BRD-A50737080 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
94046 BRD-A50737080 JURKAT 0.37 uM 24 h -0.23 -0.96 0.1 -0.23 -0.79 0.1
94075 BRD-A50737080 MCF??7.00 10 uM 24 h 0.19 0.79 0.0 -0.37 -1.23 1.28
94126 BRD-A50737080 NEU 3.33 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
94183 BRD-A50737080 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94206 BRD-A50737080 PC3 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
94261 BRD-A50737080 SHSY5Y 1.11 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.34
94312 BRD-A50737080 SKL 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94356 BRD-A50737080 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.22 0.77 0.05
94394 BRD-A50737080 YAPC 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100201 BRD-A50737080 U2OS 10 uM 6 h 0.15 0.61 0.0 -0.3 -1.01 0.58
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).