CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01218
Pert ID:	BRD-K43164539
Compound Name:	cholic-acid
Targets:	ADH1C\|CES1\|COX4I1\|COX5A\|COX5B\|COX6A2\|COX6B1\|COX6C\|COX7A1\|COX7B\|COX7C\|COX8A\|ESRRG\|FABP6\|FECH\|GPBAR1\|MT-CO1\|MT-CO2\|MT-CO3\|PLA2G1B
MoA:	bile acid
SMILES:	C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
34107	BRD-K43164539	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
34624	BRD-K43164539	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
34890	BRD-K43164539	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.26	-0.89	0.26
36268	BRD-K43164539	PHH	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
36566	BRD-K43164539	SKB	10 uM	24 h	-0.28	-1.16	0.48	-0.32	-1.06	0.75
36824	BRD-K43164539	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
98811	BRD-K43164539	NPC	10 uM	6 h	0.0	0.0	0.0	-0.38	-1.28	1.45
99043	BRD-K43164539	NEU	10 uM	6 h	-0.22	-0.92	0.06	-0.27	-0.92	0.34
123247	BRD-K43164539	A375	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123294	BRD-K43164539	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123321	BRD-K43164539	HELA	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
123354	BRD-K43164539	HT29	0.04 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123405	BRD-K43164539	MDAMB231	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123504	BRD-K43164539	YAPC	0.37 uM	24 h	-0.26	-1.08	0.31	0.0	0.0	0.0
131559	BRD-K43164539	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131599	BRD-K43164539	HA1E	2.22 uM	24 h	0.23	0.97	0.08	0.0	0.0	0.0
131741	BRD-K43164539	HUVEC	0.03 uM	24 h	-0.23	-0.96	0.09	0.0	0.0	0.0
131795	BRD-K43164539	JURKAT	0.74 uM	24 h	0.25	1.06	0.18	0.0	0.0	0.0
131831	BRD-K43164539	MCF10A	0.08 uM	24 h	0.0	0.0	0.0	0.28	1.0	0.42
131869	BRD-K43164539	MCF??7.00	0.25 uM	24 h	0.26	1.1	0.25	-0.28	-0.94	0.37
131920	BRD-K43164539	PC3	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131938	BRD-K43164539	THP1	2.22 uM	24 h	0.0	0.0	0.0	0.29	1.03	0.5

Summary