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CMap Candidate Details

Structure:
CMap ID: C01257
Pert ID: BRD-K34157611
Compound Name: cimetidine
Targets: HRH2|SLC29A4|SLC47A1|SLC47A2
MoA: histamine receptor antagonist
SMILES: CN\C(NCCSCc1nc[nH]c1C)=N/C#N
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6324 BRD-K34157611 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37638 BRD-K34157611 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38464 BRD-K34157611 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38710 BRD-K34157611 PHH 10 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
53019 BRD-K34157611 HEPG2 30 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
91159 BRD-K34157611 HUH7 12.5 uM 72 h -0.3 -1.23 0.63 0.0 0.0 0.0
99864 BRD-K34157611 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
117052 BRD-K34157611 A549 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117133 BRD-K34157611 HCC515 1.11 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.17
117227 BRD-K34157611 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
121944 BRD-K34157611 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121973 BRD-K34157611 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122079 BRD-K34157611 HUVEC 3.33 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
122179 BRD-K34157611 PC3 0.37 uM 24 h -0.27 -1.11 0.38 0.22 0.77 0.06
130191 BRD-K34157611 A375 0.08 uM 24 h -0.28 -1.17 0.49 -0.31 -1.03 0.64
130307 BRD-K34157611 HELA 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130379 BRD-K34157611 JURKAT 0.08 uM 24 h -0.36 -1.49 1.43 -0.21 -0.71 0.03
130420 BRD-K34157611 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130439 BRD-K34157611 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130467 BRD-K34157611 MDAMB231 0.03 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
130510 BRD-K34157611 THP1 0.08 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
130541 BRD-K34157611 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).