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CMap Candidate Details

Structure:
CMap ID: C01265
Pert ID: BRD-K14693417
Compound Name: cinchonine
Targets: CYP2D6
MoA: P glycoprotein inhibitor
SMILES: O[C@@H]([C@H]1C[C@@H]2CC[N@]1C[C@@H]2C=C)c1ccnc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5188 BRD-K14693417 A375 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.46
5302 BRD-K14693417 HA1E 10 uM 24 h -0.25 -1.04 0.21 0.0 0.0 0.0
5583 BRD-K14693417 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5887 BRD-K14693417 HEPG2 10 uM 6 h -0.23 -0.94 0.08 0.25 0.87 0.17
6005 BRD-K14693417 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6164 BRD-K14693417 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6330 BRD-K14693417 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.83
39299 BRD-K14693417 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40591 BRD-K14693417 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.29 1.04 0.53
40755 BRD-K14693417 NEU 10 uM 24 h -0.25 -1.03 0.2 -0.24 -0.8 0.11
41055 BRD-K14693417 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41384 BRD-K14693417 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).