Logo 1 Logo 2

CMap Candidate Details

Structure:
CMap ID: C00013
Pert ID: BRD-K41918892
Compound Name: A-769662
Targets:
MoA: AMPK activator
SMILES: Oc1ccccc1-c1ccc(cc1)-c1csc2[nH]c(=O)c(C#N)c(O)c12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
94417 BRD-K41918892 A375 0.12 uM 24 h 0.28 1.18 0.39 0.24 0.85 0.14
94451 BRD-K41918892 A549 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94488 BRD-K41918892 ASC 10 uM 24 h -0.25 -1.05 0.23 0.0 0.0 0.0
94557 BRD-K41918892 CD34 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94603 BRD-K41918892 HCC515 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94648 BRD-K41918892 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.84 0.18
94697 BRD-K41918892 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94752 BRD-K41918892 HME1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94795 BRD-K41918892 HT29 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94844 BRD-K41918892 HUVEC 0.12 uM 24 h 0.26 1.1 0.24 0.0 0.0 0.0
94897 BRD-K41918892 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94941 BRD-K41918892 MCF10A 0.12 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
94980 BRD-K41918892 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95022 BRD-K41918892 NEU 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95055 BRD-K41918892 NPC 0.12 uM 24 h 0.16 0.65 0.0 0.0 0.0 0.0
95120 BRD-K41918892 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95170 BRD-K41918892 SHSY5Y 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95237 BRD-K41918892 SKL 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95280 BRD-K41918892 THP1 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).