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CMap Candidate Details

Structure:
CMap ID: C01362
Pert ID: BRD-K48443249
Compound Name: CNX-774
Targets: BTK
MoA: Bruton's tyrosine kinase (BTK) inhibitor
SMILES: CNC(=O)c1cc(Oc2ccc(Nc3ncc(F)c(Nc4cccc(NC(=O)C=C)c4)n3)cc2)ccn1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
87296 BRD-K48443249 BJAB 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87334 BRD-K48443249 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87382 BRD-K48443249 K562 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.01 0.57
87431 BRD-K48443249 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87479 BRD-K48443249 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87533 BRD-K48443249 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87583 BRD-K48443249 OCILY10 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87635 BRD-K48443249 OCILY19 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87684 BRD-K48443249 OCILY3 10 uM 24 h -0.21 -0.86 0.02 0.0 0.0 0.0
87735 BRD-K48443249 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87782 BRD-K48443249 THP1 10 uM 24 h -0.2 -0.82 0.0 0.24 0.87 0.17
87859 BRD-K48443249 TMD8 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95540 BRD-K48443249 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95603 BRD-K48443249 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95625 BRD-K48443249 U2OS 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).