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CMap Candidate Details

Structure:
CMap ID: C00138
Pert ID: BRD-K00615600
Compound Name: AG-14361
Targets: PARP1
MoA: PARP inhibitor
SMILES: CN(C)Cc1ccc(cc1)-c1nc2cccc3C(=O)NCCn1c23
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1297 BRD-K00615600 MCF??7.00 1.11 uM 48 h 0.0 0.0 0.0 0.22 0.79 0.08
1371 BRD-K00615600 U2OS 10 uM 48 h 0.0 0.0 0.0 0.0 0.0 0.0
9325 BRD-K00615600 AGS 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9630 BRD-K00615600 H1299 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10021 BRD-K00615600 HA1E 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10143 BRD-K00615600 HCC515 25 uM 24 h 0.0 0.0 0.0 -0.26 -0.87 0.24
10430 BRD-K00615600 HCT116 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10703 BRD-K00615600 HEPG2 25 uM 6 h -0.21 -0.87 0.02 0.0 0.0 0.0
11379 BRD-K00615600 NCIH2073 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11684 BRD-K00615600 NCIH508 25 uM 6 h -0.2 -0.84 0.01 -0.29 -0.98 0.48
12235 BRD-K00615600 NOMO1 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12460 BRD-K00615600 PC3 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
12699 BRD-K00615600 SW480 25 uM 6 h 0.0 0.0 0.0 0.29 1.03 0.52
12970 BRD-K00615600 THP1 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13178 BRD-K00615600 U937 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13559 BRD-K00615600 VCAP 25 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13744 BRD-K00615600 A375 10 uM 24 h 0.3 1.24 0.51 0.28 0.99 0.41
14211 BRD-K00615600 A549 10 uM 6 h 0.0 0.0 0.0 0.25 0.9 0.22
14967 BRD-K00615600 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).