CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00139
Pert ID:	BRD-K47105409
Compound Name:	AG-490
Targets:	EGFR\|JAK2\|JAK3
MoA:	EGFR inhibitor; JAK inhibitor
SMILES:	Oc1ccc(cc1O)\C=C(/C#N)C(=O)NCc1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
2887	BRD-K47105409	HA1E	10 uM	24 h	-0.24	-0.99	0.13	0.0	0.0	0.0
3213	BRD-K47105409	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
3512	BRD-K47105409	PC3	10 uM	24 h	0.23	0.94	0.06	0.0	0.0	0.0
3811	BRD-K47105409	VCAP	10 uM	24 h	-0.24	-1.01	0.17	0.27	0.96	0.33
44410	BRD-K47105409	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
44975	BRD-K47105409	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
45270	BRD-K47105409	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45539	BRD-K47105409	HT29	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
45703	BRD-K47105409	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
46090	BRD-K47105409	NPC	10 uM	24 h	-0.27	-1.13	0.41	-0.37	-1.23	1.28
46406	BRD-K47105409	PHH	10 uM	24 h	0.29	1.2	0.42	0.0	0.0	0.0
96147	BRD-K47105409	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99573	BRD-K47105409	U2OS	15 uM	6 h	0.28	1.17	0.36	0.0	0.0	0.0

Summary