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CMap Candidate Details

Structure:
CMap ID: C01420
Pert ID: BRD-A06916187
Compound Name: CPI-613
Targets: PDHA1
MoA: pyruvate dehydrogenase inhibitor
SMILES: OC(=O)CCCCC(CCSCc1ccccc1)SCc1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
122548 BRD-A06916187 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
122579 BRD-A06916187 A549 0.125 uM 24 h 0.32 1.32 0.83 0.0 0.0 0.0
122602 BRD-A06916187 HA1E 0.37 uM 24 h 0.21 0.88 0.01 0.25 0.88 0.19
122681 BRD-A06916187 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
122724 BRD-A06916187 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
122795 BRD-A06916187 PC3 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
122817 BRD-A06916187 YAPC 1.11 uM 24 h 0.25 1.04 0.14 -0.37 -1.23 1.28
130937 BRD-A06916187 HEK293 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130969 BRD-A06916187 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131046 BRD-A06916187 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.11
131084 BRD-A06916187 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
131121 BRD-A06916187 MDAMB231 0.03 uM 24 h 0.23 0.95 0.06 0.35 1.26 1.29
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).