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CMap Candidate Details

Structure:
CMap ID: C01431
Pert ID: BRD-K78431006
Compound Name: crizotinib
Targets: ALK|MET
MoA: ALK tyrosine kinase receptor inhibitor
SMILES: C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
511 BRD-K78431006 BJAB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
545 BRD-K78431006 HBL1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
607 BRD-K78431006 K562 10 uM 4 h 0.0 0.0 0.0 0.33 1.17 0.92
648 BRD-K78431006 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
694 BRD-K78431006 MINO 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
742 BRD-K78431006 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
773 BRD-K78431006 OCILY19 2.5 uM 24 h 0.26 1.08 0.21 -0.39 -1.31 1.7
817 BRD-K78431006 OCILY3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
884 BRD-K78431006 SKMEL5 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
925 BRD-K78431006 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
945 BRD-K78431006 TMD8 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
1398 BRD-K78431006 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33527 BRD-K78431006 A375 10 uM 6 h 0.0 0.0 0.0 0.29 1.01 0.45
33931 BRD-K78431006 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34180 BRD-K78431006 ASC 10 uM 24 h -0.27 -1.12 0.38 0.0 0.0 0.0
34686 BRD-K78431006 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.23 -0.79 0.1
34963 BRD-K78431006 HEPG2 10 uM 6 h -0.18 -0.74 0.0 -0.32 -1.07 0.78
35842 BRD-K78431006 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36353 BRD-K78431006 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36649 BRD-K78431006 SKB 10 uM 24 h -0.23 -0.98 0.11 0.19 0.68 0.01
36872 BRD-K78431006 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91553 BRD-K78431006 BT20 10 uM 6 h 0.2 0.84 0.0 0.36 1.28 1.37
91714 BRD-K78431006 MDAMB231 10 uM 6 h 0.21 0.88 0.02 0.0 0.0 0.0
92153 BRD-K78431006 HS578T 3.33 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92268 BRD-K78431006 MCF??7.00 1.11 uM 3 h 0.31 1.31 0.76 -0.34 -1.13 0.99
92326 BRD-K78431006 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92357 BRD-K78431006 SKBR3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119474 BRD-K78431006 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127079 BRD-K78431006 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127119 BRD-K78431006 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127170 BRD-K78431006 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127190 BRD-K78431006 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
127328 BRD-K78431006 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135152 BRD-K78431006 HT29 2.22 uM 24 h 0.19 0.79 0.0 -0.29 -0.99 0.5
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).