CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01445
Pert ID:	BRD-K53508936
Compound Name:	CTS-1027
Targets:	MMP1\|MMP13\|MMP2\|MMP3\|MMP9
MoA:	metalloproteinase inhibitor
SMILES:	ONC(=O)C1(CS(=O)(=O)c2ccc(Oc3ccc(Cl)cc3)cc2)CCOCC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
125342	BRD-K53508936	HEK293	1.11 uM	24 h	0.0	0.0	0.0	0.23	0.81	0.09
125363	BRD-K53508936	HELA	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125467	BRD-K53508936	MCF??7.00	0.125 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125479	BRD-K53508936	MDAMB231	0.04 uM	24 h	-0.24	-0.99	0.13	0.29	1.02	0.48
125508	BRD-K53508936	PC3	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125535	BRD-K53508936	THP1	0.04 uM	24 h	-0.26	-1.06	0.26	0.0	0.0	0.0
133351	BRD-K53508936	A375	0.01 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.11
133376	BRD-K53508936	A549	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133406	BRD-K53508936	HA1E	0.01 uM	24 h	0.25	1.04	0.14	0.0	0.0	0.0
133471	BRD-K53508936	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133499	BRD-K53508936	JURKAT	0.01 uM	24 h	-0.27	-1.14	0.42	0.36	1.29	1.46
133534	BRD-K53508936	MCF10A	0.01 uM	24 h	-0.25	-1.04	0.21	-0.35	-1.18	1.15
133653	BRD-K53508936	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary