CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01453
Pert ID:	BRD-K07572174
Compound Name:	curcumin
Targets:	APP\|CA1\|CA12\|CA14\|CA2\|CA4\|CA6\|CA9\|CYP3A4\|DNMT3B\|EP300\|MMP13\|MMP9\|NOS2\|PTGS1\|PTGS2\|XDH
MoA:	cyclooxygenase inhibitor; histone acetyltransferase inhibitor; lipoxygenase inhibitor; NFkB pathway inhibitor
SMILES:	COc1cc(ccc1O)\C=C\C(=O)CC(=O)\C=C\c1ccc(O)c(OC)c1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
53350	BRD-K07572174	MCF10A	100 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95443	BRD-K07572174	U2OS	10 uM	48 h	0.0	0.0	0.0	0.0	0.0	0.0
119020	BRD-K07572174	A549	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
119144	BRD-K07572174	PC3	10 uM	24 h	0.0	0.0	0.0	-0.34	-1.13	1.0
119388	BRD-K07572174	A375	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119486	BRD-K07572174	HCC515	100 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119523	BRD-K07572174	HEPG2	30 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
119728	BRD-K07572174	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124309	BRD-K07572174	HA1E	3.33 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124328	BRD-K07572174	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124367	BRD-K07572174	HELA	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.99	0.5
124393	BRD-K07572174	HT29	10 uM	24 h	0.0	0.0	0.0	-0.29	-0.96	0.43
124471	BRD-K07572174	MCF??7.00	10 uM	24 h	0.21	0.87	0.01	0.3	1.06	0.6
124498	BRD-K07572174	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
124560	BRD-K07572174	YAPC	10 uM	24 h	0.18	0.76	0.0	0.36	1.27	1.34
132625	BRD-K07572174	THP1	2.22 uM	24 h	0.19	0.81	0.0	-0.27	-0.93	0.34

Summary