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CMap Candidate Details

Structure:
CMap ID: C01459
Pert ID: BRD-K81458380
Compound Name: CX-4945
Targets: CSNK2A1|CSNK2A2|DAPK3|HIPK3
MoA: casein kinase inhibitor
SMILES: OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
63 BRD-K81458380 BJAB 2.5 uM 4 h 0.27 1.12 0.28 0.0 0.0 0.0
96 BRD-K81458380 HBL1 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.14 1.02
155 BRD-K81458380 K562 10 uM 4 h 0.0 0.0 0.0 0.0 0.0 0.0
187 BRD-K81458380 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
227 BRD-K81458380 NALM6 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
266 BRD-K81458380 OCILY10 0.66 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
291 BRD-K81458380 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.75
341 BRD-K81458380 OCILY3 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.64
385 BRD-K81458380 SKMEL5 10 uM 24 h 0.18 0.75 0.0 -0.27 -0.92 0.31
447 BRD-K81458380 TMD8 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116764 BRD-K81458380 HCC515 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116813 BRD-K81458380 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
116905 BRD-K81458380 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125960 BRD-K81458380 A375 3.33 uM 24 h 0.22 0.92 0.04 -0.23 -0.76 0.07
125978 BRD-K81458380 A549 10 uM 24 h 0.2 0.85 0.01 0.0 0.0 0.0
125999 BRD-K81458380 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126026 BRD-K81458380 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126045 BRD-K81458380 HT29 10 uM 24 h 0.3 1.24 0.52 0.28 0.98 0.37
126113 BRD-K81458380 JURKAT 10 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
126168 BRD-K81458380 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126286 BRD-K81458380 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126332 BRD-K81458380 YAPC 3.33 uM 24 h 0.0 0.0 0.0 -0.21 -0.71 0.03
134087 BRD-K81458380 HEK293 2.22 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
134201 BRD-K81458380 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134250 BRD-K81458380 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
134282 BRD-K81458380 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).