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CMap Candidate Details

Structure:
CMap ID: C01461
Pert ID: BRD-K12787259
Compound Name: CX-5461
Targets:
MoA: RNA polymerase inhibitor
SMILES: CN1CCCN(CC1)c1ccc2c(n1)n1c3ccccc3sc1c(C(=O)NCc1cnc(C)cn1)c2=O
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
93622 BRD-K12787259 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93662 BRD-K12787259 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93725 BRD-K12787259 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93801 BRD-K12787259 HCC515 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
93935 BRD-K12787259 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.81
93994 BRD-K12787259 HUVEC 10 uM 24 h -0.38 -1.58 2.12 -0.37 -1.26 1.38
94035 BRD-K12787259 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94067 BRD-K12787259 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94115 BRD-K12787259 NEU 3.33 uM 24 h 0.19 0.79 0.0 0.25 0.9 0.21
94160 BRD-K12787259 NPC 0.37 uM 24 h 0.25 1.05 0.17 -0.25 -0.85 0.19
94249 BRD-K12787259 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94300 BRD-K12787259 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94345 BRD-K12787259 THP1 10 uM 24 h -0.26 -1.1 0.34 -0.27 -0.91 0.31
122240 BRD-K12787259 A375 0.37 uM 24 h 0.0 0.0 0.0 -0.21 -0.7 0.03
122293 BRD-K12787259 HA1E 1.11 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
122312 BRD-K12787259 HEK293 10 uM 24 h 0.24 1.0 0.11 0.0 0.0 0.0
130656 BRD-K12787259 HELA 2.22 uM 24 h 0.3 1.24 0.52 -0.37 -1.24 1.31
130697 BRD-K12787259 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.33 -1.1 0.87
130735 BRD-K12787259 MCF10A 2.22 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
130778 BRD-K12787259 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130808 BRD-K12787259 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130827 BRD-K12787259 YAPC 0.25 uM 24 h 0.0 0.0 0.0 -0.41 -1.38 2.02
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).