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CMap Candidate Details

Structure:
CMap ID: C01469
Pert ID: BRD-K79501723
Compound Name: cyclizine
Targets: HRH1|SULT1E1
MoA: histamine receptor modulator
SMILES: CN1CCN(CC1)C(c1ccccc1)c1ccccc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
127058 BRD-K79501723 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
127082 BRD-K79501723 HEK293 3.33 uM 24 h 0.31 1.3 0.69 0.24 0.86 0.15
127123 BRD-K79501723 HELA 0.125 uM 24 h 0.18 0.74 0.0 0.35 1.22 1.15
127300 BRD-K79501723 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135023 BRD-K79501723 A375 0.74 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
135067 BRD-K79501723 A549 0.01 uM 24 h 0.0 0.0 0.0 -0.15 -0.51 0.0
135155 BRD-K79501723 HT29 2.22 uM 24 h -0.28 -1.15 0.44 0.18 0.65 0.01
135193 BRD-K79501723 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.21 0.75 0.04
135224 BRD-K79501723 MCF10A 0.03 uM 24 h -0.22 -0.91 0.06 -0.32 -1.06 0.74
135240 BRD-K79501723 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135293 BRD-K79501723 MDAMB231 0.74 uM 24 h 0.27 1.14 0.32 -0.32 -1.07 0.76
135302 BRD-K79501723 PC3 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
135338 BRD-K79501723 YAPC 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).