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CMap Candidate Details

Structure:
CMap ID: C01470
Pert ID: BRD-K42348709
Compound Name: cyclobenzaprine
Targets: HTR2A
MoA: adrenergic receptor agonist; serotonin receptor agonist
SMILES: CN(C)CCC=C1c2ccccc2C=Cc2ccccc12
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123242 BRD-K42348709 A375 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123278 BRD-K42348709 HA1E 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
123291 BRD-K42348709 HEK293 10 uM 24 h 0.0 0.0 0.0 0.33 1.18 0.99
123350 BRD-K42348709 HT29 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.99 0.51
123402 BRD-K42348709 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.36 1.29 1.49
123499 BRD-K42348709 YAPC 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
131556 BRD-K42348709 A549 0.03 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
131667 BRD-K42348709 HELA 2.22 uM 24 h 0.33 1.36 0.97 -0.37 -1.25 1.35
131736 BRD-K42348709 HUVEC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131790 BRD-K42348709 JURKAT 0.03 uM 24 h 0.22 0.9 0.02 -0.29 -0.97 0.46
131829 BRD-K42348709 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131865 BRD-K42348709 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131919 BRD-K42348709 PC3 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131937 BRD-K42348709 THP1 2.22 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).