CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01492
Pert ID:	BRD-K28143534
Compound Name:	cyproheptadine
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|CHRM1\|CHRM2\|CHRM3\|HRH1\|HTR2A\|HTR2C\|HTR6\|HTR7
MoA:	histamine receptor antagonist
SMILES:	CN1CCC(CC1)=C1c2ccccc2C=Cc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
22270	BRD-K28143534	A549	10 uM	6 h	0.0	0.0	0.0	-0.31	-1.05	0.7
22731	BRD-K28143534	HCC515	10 uM	6 h	0.0	0.0	0.0	-0.36	-1.22	1.25
23018	BRD-K28143534	HEPG2	10 uM	6 h	0.0	0.0	0.0	-0.36	-1.2	1.17
23323	BRD-K28143534	HT29	10 uM	6 h	0.25	1.05	0.16	0.0	0.0	0.0
23561	BRD-K28143534	MCF??7.00	10 uM	24 h	0.32	1.32	0.82	0.0	0.0	0.0
24139	BRD-K28143534	VCAP	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
91495	BRD-K28143534	HUH7	12 uM	72 h	-0.3	-1.24	0.67	0.31	1.09	0.67
96017	BRD-K28143534	PHH	3.33 uM	24 h	-0.25	-1.06	0.25	-0.24	-0.79	0.11
99795	BRD-K28143534	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
119942	BRD-K28143534	A375	10 uM	24 h	0.0	0.0	0.0	-0.24	-0.8	0.12
120023	BRD-K28143534	HA1E	10 uM	24 h	0.21	0.86	0.01	-0.32	-1.09	0.82
120181	BRD-K28143534	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
120213	BRD-K28143534	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128828	BRD-K28143534	HELA	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary