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CMap Candidate Details

Structure:
CMap ID: C01497
Pert ID: BRD-K23363278
Compound Name: CYT-997
Targets: TUBB
MoA: tubulin polymerization inhibitor
SMILES: CCC[C@H](Nc1nc(ncc1C)-c1ccc(NC(=O)NCC)c(OC)c1)c1cccnc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9387 BRD-K23363278 AGS 1.11 uM 6 h 0.0 0.0 0.0 -0.32 -1.06 0.75
9699 BRD-K23363278 H1299 1.11 uM 6 h 0.0 0.0 0.0 -0.4 -1.34 1.86
10244 BRD-K23363278 HCC515 1.11 uM 6 h -0.24 -1.0 0.15 0.0 0.0 0.0
10759 BRD-K23363278 HEPG2 1.11 uM 6 h -0.24 -1.01 0.16 0.0 0.0 0.0
11449 BRD-K23363278 NCIH2073 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12014 BRD-K23363278 NCIH596 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12290 BRD-K23363278 NOMO1 1.11 uM 6 h 0.0 0.0 0.0 -0.34 -1.16 1.09
12426 BRD-K23363278 PC3 1.11 uM 24 h -0.28 -1.16 0.45 -0.28 -0.94 0.37
12761 BRD-K23363278 SW480 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12924 BRD-K23363278 THP1 1.11 uM 6 h 0.2 0.83 0.0 -0.25 -0.86 0.21
13241 BRD-K23363278 U937 1.11 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.42
13460 BRD-K23363278 VCAP 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120957 BRD-K23363278 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121045 BRD-K23363278 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.12
121113 BRD-K23363278 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129098 BRD-K23363278 A375 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129117 BRD-K23363278 A549 2.22 uM 24 h -0.24 -0.98 0.12 -0.29 -0.99 0.5
129137 BRD-K23363278 HA1E 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129165 BRD-K23363278 HELA 2.22 uM 3 h 0.0 0.0 0.0 -0.47 -1.57 15.65
129192 BRD-K23363278 HT29 0.74 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).