CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01522
Pert ID:	BRD-K09951645
Compound Name:	dabrafenib
Targets:	BRAF\|LIMK1\|NEK11\|RAF1\|SIK1
MoA:	RAF inhibitor
SMILES:	CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
1165	BRD-K09951645	MCF??7.00	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
1204	BRD-K09951645	PC3	10 uM	24 h	0.21	0.89	0.02	0.29	1.02	0.48
1231	BRD-K09951645	A549	10 uM	24 h	0.24	1.01	0.12	0.0	0.0	0.0
1396	BRD-K09951645	U2OS	10 uM	6 h	0.0	0.0	0.0	-0.34	-1.14	1.03
94512	BRD-K09951645	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94548	BRD-K09951645	CD34	10 uM	24 h	-0.2	-0.84	0.01	-0.36	-1.22	1.25
94639	BRD-K09951645	HEK293	10 uM	24 h	0.0	0.0	0.0	0.36	1.29	1.47
94689	BRD-K09951645	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94743	BRD-K09951645	HME1	10 uM	24 h	0.21	0.88	0.01	0.46	1.62	2.4
94835	BRD-K09951645	HUVEC	0.12 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94888	BRD-K09951645	JURKAT	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
94934	BRD-K09951645	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	-0.41	-1.38	2.02
95014	BRD-K09951645	NEU	1.11 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
95076	BRD-K09951645	NPC	0.04 uM	24 h	0.0	0.0	0.0	0.33	1.18	0.97
95161	BRD-K09951645	SHSY5Y	10 uM	24 h	0.0	0.0	0.0	0.29	1.01	0.46
95208	BRD-K09951645	SKL	10 uM	24 h	0.22	0.9	0.02	0.0	0.0	0.0
95271	BRD-K09951645	THP1	0.12 uM	24 h	0.21	0.88	0.02	0.0	0.0	0.0
117345	BRD-K09951645	A375	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
117424	BRD-K09951645	HA1E	3.33 uM	24 h	0.27	1.15	0.32	0.0	0.0	0.0
117469	BRD-K09951645	HCC515	3.33 uM	24 h	0.0	0.0	0.0	-0.51	-1.73	15.65
117516	BRD-K09951645	HEPG2	3.33 uM	24 h	-0.2	-0.84	0.01	-0.31	-1.05	0.7
129303	BRD-K09951645	HT29	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
129377	BRD-K09951645	YAPC	0.08 uM	24 h	0.0	0.0	0.0	-0.32	-1.09	0.81

Summary