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CMap Candidate Details

Structure:
CMap ID: C01524
Pert ID: BRD-K56957086
Compound Name: dacinostat
Targets: HDAC1|HDAC2|HDAC3|HDAC4|HDAC5|HDAC6|HDAC7|HDAC8|HDAC9
MoA: HDAC inhibitor
SMILES: OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(\C=C\C(=O)NO)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33707 BRD-K56957086 A375 10 uM 6 h -0.28 -1.17 0.48 0.0 0.0 0.0
34130 BRD-K56957086 ASC 10 uM 24 h 0.26 1.07 0.2 -0.31 -1.04 0.67
34646 BRD-K56957086 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34913 BRD-K56957086 HEPG2 10 uM 6 h -0.28 -1.15 0.43 0.0 0.0 0.0
35586 BRD-K56957086 NEU 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
35803 BRD-K56957086 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36289 BRD-K56957086 PHH 10 uM 24 h 0.0 0.0 0.0 -0.41 -1.37 2.02
36590 BRD-K56957086 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36838 BRD-K56957086 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95317 BRD-K56957086 A549 0.12 uM 48 h -0.25 -1.03 0.2 0.0 0.0 0.0
95398 BRD-K56957086 U2OS 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123894 BRD-K56957086 HEK293 0.04 uM 24 h -0.22 -0.9 0.04 -0.35 -1.17 1.12
123994 BRD-K56957086 JURKAT 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124048 BRD-K56957086 MCF10A 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124176 BRD-K56957086 THP1 0.04 uM 24 h -0.21 -0.89 0.03 -0.29 -0.99 0.5
124229 BRD-K56957086 YAPC 0.04 uM 24 h 0.18 0.76 0.0 0.32 1.15 0.88
132163 BRD-K56957086 HA1E 0.01 uM 24 h -0.26 -1.1 0.33 0.0 0.0 0.0
132192 BRD-K56957086 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
132224 BRD-K56957086 HT29 0.01 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
132251 BRD-K56957086 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132274 BRD-K56957086 MDAMB231 0.08 uM 24 h 0.25 1.06 0.19 -0.26 -0.87 0.23
132294 BRD-K56957086 PC3 0.01 uM 24 h 0.28 1.18 0.39 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).