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CMap Candidate Details

Structure:
CMap ID: C01526
Pert ID: BRD-K57169635
Compound Name: dacomitinib
Targets: EGFR|ERBB2|ERBB4
MoA: EGFR inhibitor
SMILES: COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN1CCCCC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
92928 BRD-K57169635 ASC 10 uM 24 h -0.18 -0.76 0.0 0.0 0.0 0.0
92991 BRD-K57169635 CD34 10 uM 24 h 0.27 1.14 0.32 0.0 0.0 0.0
93037 BRD-K57169635 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93079 BRD-K57169635 HEK293 10 uM 24 h 0.3 1.25 0.56 0.35 1.22 1.15
93167 BRD-K57169635 HEPG2 10 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
93216 BRD-K57169635 HUVEC 10 uM 24 h 0.23 0.95 0.06 -0.33 -1.12 0.94
93354 BRD-K57169635 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
93416 BRD-K57169635 NPC 3.33 uM 24 h 0.0 0.0 0.0 -0.3 -1.02 0.61
93481 BRD-K57169635 SKL 10 uM 24 h 0.23 0.98 0.09 0.32 1.13 0.82
93579 BRD-K57169635 YAPC 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.62
123794 BRD-K57169635 A375 3.33 uM 24 h 0.31 1.28 0.61 0.0 0.0 0.0
123836 BRD-K57169635 A549 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.13
123942 BRD-K57169635 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.74
123963 BRD-K57169635 HT29 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123998 BRD-K57169635 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124051 BRD-K57169635 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124095 BRD-K57169635 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
124153 BRD-K57169635 PC3 10 uM 24 h -0.21 -0.88 0.03 0.29 1.03 0.51
124180 BRD-K57169635 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).