CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01535
Pert ID:	BRD-A92537424
Compound Name:	danazol
Targets:	AR\|CCL2\|ESR1\|GNRHR\|GNRHR2\|PGR
MoA:	estrogen receptor antagonist; progesterone receptor agonist
SMILES:	C[C@]12CCC3C(CCC4=Cc5oncc5C[C@]34C)C1CC[C@@]2(O)C#C
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5560	BRD-A92537424	HCC515	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
6500	BRD-A92537424	VCAP	10 uM	6 h	0.0	0.0	0.0	-0.29	-0.99	0.51
42241	BRD-A92537424	ASC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
42581	BRD-A92537424	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
43439	BRD-A92537424	NPC	10 uM	24 h	0.24	0.99	0.1	-0.41	-1.39	2.02
43747	BRD-A92537424	PHH	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.88	0.24
95328	BRD-A92537424	A549	10 uM	48 h	-0.29	-1.23	0.63	-0.26	-0.86	0.21
95371	BRD-A92537424	MCF??7.00	10 uM	48 h	-0.22	-0.91	0.05	0.0	0.0	0.0
95479	BRD-A92537424	U2OS	0.12 uM	6 h	-0.25	-1.05	0.24	-0.33	-1.11	0.92
128415	BRD-A92537424	HEK293	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128491	BRD-A92537424	HT29	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128524	BRD-A92537424	JURKAT	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
128580	BRD-A92537424	MCF10A	10 uM	24 h	-0.21	-0.87	0.02	0.0	0.0	0.0
128618	BRD-A92537424	MDAMB231	0.04 uM	24 h	0.0	0.0	0.0	-0.27	-0.9	0.29
128670	BRD-A92537424	PC3	0.125 uM	24 h	0.0	0.0	0.0	0.29	1.02	0.47
128697	BRD-A92537424	THP1	0.125 uM	24 h	0.0	0.0	0.0	0.23	0.82	0.1
136160	BRD-A92537424	A375	0.03 uM	24 h	-0.2	-0.85	0.01	0.41	1.45	2.22
136205	BRD-A92537424	HA1E	0.01 uM	24 h	0.0	0.0	0.0	0.28	0.97	0.36
136248	BRD-A92537424	HELA	0.25 uM	24 h	0.34	1.42	1.09	-0.31	-1.06	0.73
136377	BRD-A92537424	YAPC	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary