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CMap Candidate Details

Structure:
CMap ID: C01540
Pert ID: BRD-K81272440
Compound Name: dantrolene
Targets: RYR1|RYR3
MoA: calcium channel blocker
SMILES: [O-][N+](=O)c1ccc(cc1)-c1ccc(\C=N\N2CC(=O)NC2=O)o1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3267 BRD-K81272440 HCC515 10 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
3872 BRD-K81272440 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42483 BRD-K81272440 ASC 10 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
42793 BRD-K81272440 HEPG2 10 uM 6 h -0.19 -0.8 0.0 -0.23 -0.76 0.08
43658 BRD-K81272440 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
50059 BRD-K81272440 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
50242 BRD-K81272440 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
126071 BRD-K81272440 HUVEC 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126112 BRD-K81272440 JURKAT 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126167 BRD-K81272440 MCF10A 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126214 BRD-K81272440 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126232 BRD-K81272440 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.68
126255 BRD-K81272440 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126285 BRD-K81272440 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.32 -1.09 0.82
133998 BRD-K81272440 A375 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134086 BRD-K81272440 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134138 BRD-K81272440 HELA 0.01 uM 24 h 0.24 1.01 0.12 0.0 0.0 0.0
134175 BRD-K81272440 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134306 BRD-K81272440 YAPC 0.25 uM 24 h -0.18 -0.76 0.0 -0.22 -0.74 0.05
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).