CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01542
Pert ID:	BRD-K07881437
Compound Name:	danusertib
Targets:	AURKA\|AURKB\|AURKC\|FGFR1\|NTRK1\|RET\|SLK
MoA:	Aurora kinase inhibitor; growth factor receptor inhibitor
SMILES:	CO[C@@H](C(=O)N1Cc2[nH]nc(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
30357	BRD-K07881437	ASC	10 uM	24 h	0.0	0.0	0.0	0.4	1.41	2.18
30961	BRD-K07881437	HCC515	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
31263	BRD-K07881437	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
31574	BRD-K07881437	HT29	10 uM	6 h	0.0	0.0	0.0	0.26	0.91	0.23
31992	BRD-K07881437	MCF??7.00	10 uM	6 h	-0.32	-1.34	0.98	-0.17	-0.58	0.0
32348	BRD-K07881437	NPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
32734	BRD-K07881437	PC3	10 uM	6 h	0.0	0.0	0.0	0.32	1.14	0.85
32940	BRD-K07881437	SKB	10 uM	24 h	0.28	1.16	0.36	0.0	0.0	0.0
33242	BRD-K07881437	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.3	-1.02	0.59
95495	BRD-K07881437	A549	10 uM	24 h	0.21	0.87	0.01	0.31	1.08	0.66
95643	BRD-K07881437	U2OS	0.08 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121139	BRD-K07881437	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121209	BRD-K07881437	HA1E	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121244	BRD-K07881437	HELA	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
121337	BRD-K07881437	YAPC	10 uM	24 h	0.0	0.0	0.0	0.22	0.79	0.08

Summary