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CMap Candidate Details

Structure:
CMap ID: C01563
Pert ID: BRD-K82767007
Compound Name: dazoxiben
Targets: TBXAS1
MoA: thromboxane synthase inhibitor
SMILES: OC(=O)c1ccc(OCCn2ccnc2)cc1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
126051 BRD-K82767007 HT29 10 uM 24 h -0.22 -0.94 0.08 0.24 0.84 0.13
126081 BRD-K82767007 HUVEC 10 uM 24 h 0.23 0.96 0.07 0.36 1.27 1.33
126126 BRD-K82767007 JURKAT 0.125 uM 24 h -0.29 -1.22 0.62 0.33 1.17 0.92
126179 BRD-K82767007 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.19 -0.63 0.0
126262 BRD-K82767007 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126298 BRD-K82767007 THP1 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.34
134006 BRD-K82767007 A375 2.22 uM 24 h 0.25 1.05 0.17 0.0 0.0 0.0
134037 BRD-K82767007 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134065 BRD-K82767007 HA1E 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134100 BRD-K82767007 HEK293 0.01 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
134147 BRD-K82767007 HELA 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134228 BRD-K82767007 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134257 BRD-K82767007 MDAMB231 2.22 uM 24 h -0.24 -1.0 0.14 0.29 1.03 0.49
134312 BRD-K82767007 YAPC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).