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CMap Candidate Details

Structure:
CMap ID: C01575
Pert ID: BRD-K79254416
Compound Name: decitabine
Targets: DNMT1|DNMT3A
MoA: DNA methyltransferase inhibitor
SMILES: Nc1ncn([C@H]2C[C@H](O)[C@@H](CO)O2)c(=O)n1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
32239 BRD-K79254416 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33140 BRD-K79254416 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33357 BRD-K79254416 VCAP 10 uM 24 h 0.29 1.21 0.47 -0.25 -0.83 0.17
93625 BRD-K79254416 A549 0.37 uM 24 h -0.22 -0.91 0.05 0.26 0.92 0.25
93666 BRD-K79254416 ASC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93731 BRD-K79254416 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93856 BRD-K79254416 HEK293 3.33 uM 24 h 0.23 0.95 0.06 0.28 0.98 0.37
93897 BRD-K79254416 HELA 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93998 BRD-K79254416 HUVEC 10 uM 24 h 0.29 1.23 0.5 0.32 1.12 0.76
94040 BRD-K79254416 JURKAT 3.33 uM 24 h 0.0 0.0 0.0 0.29 1.02 0.48
94162 BRD-K79254416 NPC 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
94255 BRD-K79254416 SHSY5Y 0.04 uM 24 h 0.0 0.0 0.0 -0.24 -0.81 0.14
94306 BRD-K79254416 SKL 10 uM 24 h -0.19 -0.78 0.0 0.0 0.0 0.0
94350 BRD-K79254416 THP1 0.04 uM 24 h 0.0 0.0 0.0 -0.4 -1.34 1.85
95553 BRD-K79254416 MCF??7.00 10 uM 24 h 0.29 1.22 0.48 0.0 0.0 0.0
95660 BRD-K79254416 U2OS 0.12 uM 48 h -0.23 -0.95 0.09 -0.27 -0.9 0.27
118479 BRD-K79254416 HA1E 10 uM 24 h -0.22 -0.92 0.06 0.0 0.0 0.0
118523 BRD-K79254416 HCC515 10 uM 24 h 0.27 1.14 0.31 0.25 0.88 0.19
118568 BRD-K79254416 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.16 1.11
126354 BRD-K79254416 A375 0.04 uM 24 h 0.0 0.0 0.0 0.43 1.52 2.28
126506 BRD-K79254416 MCF10A 0.37 uM 24 h 0.23 0.95 0.06 0.0 0.0 0.0
126547 BRD-K79254416 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
126567 BRD-K79254416 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134447 BRD-K79254416 HT29 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134643 BRD-K79254416 YAPC 2.22 uM 24 h 0.19 0.79 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).