CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01610
Pert ID:	BRD-K60762818
Compound Name:	desipramine
Targets:	ADRA1A\|ADRA1B\|ADRA1D\|ADRA2A\|ADRA2B\|ADRA2C\|ADRB1\|ADRB2\|CHRM1\|CHRM2\|CHRM3\|CHRM4\|CHRM5\|DRD2\|HRH1\|HTR1A\|HTR2A\|HTR2C\|SLC6A2\|SLC6A4\|SMPD1
MoA:	tricyclic antidepressant
SMILES:	CNCCCN1c2ccccc2CCc2ccccc12
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5347	BRD-K60762818	HA1E	10 uM	24 h	0.19	0.77	0.0	0.35	1.25	1.29
5793	BRD-K60762818	HCC515	10 uM	6 h	0.24	1.0	0.1	0.31	1.11	0.72
6576	BRD-K60762818	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
41805	BRD-K60762818	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
42117	BRD-K60762818	A549	10 uM	6 h	0.0	0.0	0.0	0.23	0.81	0.09
42414	BRD-K60762818	ASC	10 uM	24 h	0.0	0.0	0.0	0.32	1.12	0.78
42731	BRD-K60762818	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
43031	BRD-K60762818	HT29	10 uM	6 h	0.22	0.93	0.05	0.47	1.67	2.47
43212	BRD-K60762818	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.67
43595	BRD-K60762818	NPC	10 uM	24 h	0.0	0.0	0.0	0.27	0.95	0.31
43899	BRD-K60762818	PHH	10 uM	24 h	0.32	1.32	0.79	0.33	1.16	0.9
44155	BRD-K60762818	SKB	10 uM	24 h	-0.2	-0.81	0.0	-0.24	-0.81	0.13
50851	BRD-K60762818	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary