CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01632
Pert ID:	BRD-K44309363
Compound Name:	dexniguldipine
Targets:	ADORA3
MoA:	calmodulin antagonist
SMILES:	COC(=O)C1=C(C)NC(C)=C([C@@H]1c1cccc(c1)[N+]([O-])=O)C(=O)OCCCN1CCC(CC1)(c1ccccc1)c1ccccc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
90607	BRD-K44309363	HCT116	3.33 uM	24 h	-0.26	-1.07	0.28	0.0	0.0	0.0
90698	BRD-K44309363	MCF10A	0.37 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.26
98007	BRD-K44309363	HA1E	3.33 uM	24 h	0.23	0.95	0.06	0.31	1.11	0.72
98094	BRD-K44309363	P1A82	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99550	BRD-K44309363	U2OS	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
123251	BRD-K44309363	A375	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123297	BRD-K44309363	HEK293	0.04 uM	24 h	0.34	1.43	1.11	0.28	0.99	0.41
123357	BRD-K44309363	HT29	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123384	BRD-K44309363	MCF??7.00	10 uM	24 h	0.18	0.76	0.0	0.0	0.0	0.0
123406	BRD-K44309363	MDAMB231	0.125 uM	24 h	0.0	0.0	0.0	0.23	0.81	0.09
123440	BRD-K44309363	PC3	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
123474	BRD-K44309363	THP1	10 uM	24 h	0.0	0.0	0.0	0.24	0.87	0.17
123510	BRD-K44309363	YAPC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131566	BRD-K44309363	A549	0.25 uM	24 h	0.24	1.0	0.1	0.23	0.8	0.08
131671	BRD-K44309363	HELA	2.22 uM	24 h	0.23	0.95	0.06	0.0	0.0	0.0
131748	BRD-K44309363	HUVEC	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
131803	BRD-K44309363	JURKAT	0.01 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary