CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C00167
Pert ID:	BRD-A14966924
Compound Name:	alaproclate
Targets:	SLC6A4
MoA:	serotonin receptor antagonist
SMILES:	CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
5498	BRD-A14966924	HCC515	10 uM	24 h	0.22	0.9	0.02	0.0	0.0	0.0
5825	BRD-A14966924	HEPG2	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
6381	BRD-A14966924	VCAP	10 uM	24 h	0.0	0.0	0.0	-0.31	-1.04	0.68
37445	BRD-A14966924	ASC	10 uM	24 h	-0.31	-1.29	0.79	-0.38	-1.27	1.43
38297	BRD-A14966924	NPC	10 uM	24 h	0.0	0.0	0.0	-0.36	-1.22	1.24
38821	BRD-A14966924	SKB	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122267	BRD-A14966924	A375	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122303	BRD-A14966924	HA1E	3.33 uM	24 h	-0.25	-1.05	0.22	0.0	0.0	0.0
122335	BRD-A14966924	HELA	0.04 uM	24 h	-0.2	-0.84	0.01	0.0	0.0	0.0
122446	BRD-A14966924	PC3	10 uM	24 h	-0.22	-0.9	0.04	0.0	0.0	0.0
122490	BRD-A14966924	THP1	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
122524	BRD-A14966924	YAPC	1.11 uM	24 h	-0.25	-1.04	0.22	0.0	0.0	0.0
130568	BRD-A14966924	A549	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
130635	BRD-A14966924	HEK293	0.74 uM	24 h	0.0	0.0	0.0	0.23	0.82	0.11
130720	BRD-A14966924	HT29	0.74 uM	24 h	0.0	0.0	0.0	0.23	0.83	0.11
130746	BRD-A14966924	MCF10A	0.74 uM	24 h	-0.31	-1.28	0.77	-0.2	-0.68	0.02
130766	BRD-A14966924	MCF??7.00	0.25 uM	24 h	0.0	0.0	0.0	-0.24	-0.81	0.14
130793	BRD-A14966924	MDAMB231	0.03 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary