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CMap Candidate Details

Structure:
CMap ID: C01675
Pert ID: BRD-K45542189
Compound Name: diethylcarbamazine
Targets: ALOX5|PTGS1
MoA: lipoxygenase inhibitor
SMILES: CCN(CC)C(=O)N1CCN(C)CC1
InchiKey:
Compound Aliases:

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5637 BRD-K45542189 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5919 BRD-K45542189 HEPG2 10 uM 6 h 0.24 0.98 0.09 -0.25 -0.84 0.18
6191 BRD-K45542189 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6554 BRD-K45542189 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41772 BRD-K45542189 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42369 BRD-K45542189 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43557 BRD-K45542189 NPC 10 uM 24 h 0.18 0.74 0.0 0.0 0.0 0.0
43857 BRD-K45542189 PHH 10 uM 24 h 0.3 1.23 0.5 -0.27 -0.89 0.27
44122 BRD-K45542189 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
95365 BRD-K45542189 MCF??7.00 10 uM 48 h 0.0 0.0 0.0 -0.32 -1.08 0.81
99561 BRD-K45542189 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124592 BRD-K45542189 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124634 BRD-K45542189 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124649 BRD-K45542189 HELA 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
124779 BRD-K45542189 MDAMB231 10 uM 24 h -0.18 -0.76 0.0 0.28 0.98 0.38
124906 BRD-K45542189 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132713 BRD-K45542189 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132805 BRD-K45542189 HT29 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132824 BRD-K45542189 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132856 BRD-K45542189 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132923 BRD-K45542189 THP1 0.74 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).