CKDkb: a knowledge base and platform for drug development against non-alcoholic fatty liver disease

Structure:

CMap ID:	C01700
Pert ID:	BRD-K48722258
Compound Name:	dilazep
Targets:	SLC29A1
MoA:	adenosine reuptake inhibitor
SMILES:	COc1cc(cc(OC)c1OC)C(=O)OCCCN1CCCN(CCCOC(=O)c2cc(OC)c(OC)c(OC)c2)CC1
InchiKey:
Compound Aliases:

The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).
Score ID	Pert ID	Cell Line	Pert Dose	Pert Time	Raw Score (GSE126848)	Normalized Score (GSE126848)	fdr_q_nlog10 (GSE126848)	Raw Score (GSE135251)	Normalized Score (GSE135251)	fdr_q_nlog10 (GSE135251)
6885	BRD-K48722258	A375	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
7003	BRD-K48722258	A549	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
7451	BRD-K48722258	HA1E	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
8005	BRD-K48722258	HT29	10 uM	6 h	0.0	0.0	0.0	-0.38	-1.29	1.52
8821	BRD-K48722258	VCAP	10 uM	6 h	0.0	0.0	0.0	0.0	0.0	0.0
91202	BRD-K48722258	HUH7	6.66 uM	72 h	0.0	0.0	0.0	0.0	0.0	0.0
97579	BRD-K48722258	NKDBA	0.37 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
99594	BRD-K48722258	U2OS	10 uM	6 h	0.21	0.87	0.01	0.0	0.0	0.0
125659	BRD-K48722258	HEK293	3.33 uM	24 h	0.18	0.76	0.0	0.0	0.0	0.0
125681	BRD-K48722258	HELA	3.33 uM	24 h	0.34	1.42	1.03	0.0	0.0	0.0
125752	BRD-K48722258	HUVEC	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125809	BRD-K48722258	MCF10A	1.11 uM	24 h	0.0	0.0	0.0	-0.28	-0.95	0.41
125834	BRD-K48722258	MCF??7.00	10 uM	24 h	0.0	0.0	0.0	-0.26	-0.89	0.26
125857	BRD-K48722258	MDAMB231	10 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
125950	BRD-K48722258	YAPC	10 uM	24 h	0.22	0.91	0.03	0.44	1.54	2.31
133834	BRD-K48722258	JURKAT	2.22 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0
133955	BRD-K48722258	PC3	0.01 uM	24 h	0.3	1.25	0.54	0.0	0.0	0.0
133989	BRD-K48722258	THP1	0.74 uM	24 h	0.0	0.0	0.0	0.0	0.0	0.0

Summary